The International Subarachnoid Aneurysm Trial (ISAT) demonstrated improved one-year clinical outcomes for patients with ruptured. It seems likely that the International Subarachnoid Aneurysm Trial (ISAT) will have a comparable effect on aneurysm surgery. Even before the publication of the. The recent publication of the initial data from the International Subarachnoid Aneurysm Trial (ISAT) represents a landmark in the evolution of.

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ISAT sought to measure outcomes of cerebral aneurysm patients at 2 and 12 months using a type of a Rankin scale.

International Subarachnoid Aneurysm Trial – Wikipedia

The first results were published in The Lancet inand the 10 year data were published again in The Lancet in early September Long-term follow up continues. Risk of aneurysm recurrence in patients with clipped cerebral aneurysms.

Coils or clips in subarachnoid haemorrhage? Results of direct surgery for aneurismal subarachnoid hemorrhage: Mayer S, Kreiter K.

International Subarachnoid Aneurysm Trial

International subarachnoid aneurysm trial ISAT of anurysm clipping versus endovascular coiling in patients with ruptured intracranial aneurysms: More on ISAT [letter]. Articles Current Issue Ahead of print Archive.


The International Subarachnoid Aneurysm Trial ISAT was a large multicentre, prospective randomised clinical medical trialcomparing the safety and efficacy of endovascular coil treatment and surgical clipping for the treatment of brain aneurysms. Updated data from the ISAT group in March shows that the higher aneurysm rate of recurrence is also associated with a higher rebleeding rate, given that the rebleed rate of aneurhsm aneurysms appears to be 8 times higher than that of clipping ieat aneurysms in this study.

This page was andurysm edited on 13 Decemberat Critical appraisal of the international subarachnoid aneurysm trial ISAT. What percentage of surgically clipped aneurysms have residual necks?

The study began in The primary outcome was death or dependence at 1 year defined by a modified Rankin scale of Views Read Edit View history. Scott Med J ;2: ISAT was criticised on a number of factors, many related to the randomization of the patient population.

Treatment of intracranial aneurysms by embolization with coils. Secondary outcomes included rebleeding from the treated aneurysm and risk of seizures. They reported finding outcomes similar to the ISAT. The risk of late rebleeding is low, but is more common after endovascular coiling than after neurosurgical clipping. How to cite this URL: Alexander, Robert Friedrich Spetzler, Pediatric neurovascular disease: Natural history of the neck remnant of a cerebral aneurysm issat with the Guglielmi detachable coil system.



Br J Neurosurg ; Online since 20 th March ‘ Journal of Neurosurgery Neurosurgical clipping versus endovascular coiling of patients with ruptured intracranial aneurysms. Microsurgical clipping and endovascular coiling of intracranial aneurysms: Late angiographic follow-up review of surgically treated aneurysms.

Retrieved from ” https: Outcomes of early endovascular versus surgical treatment of ruptured cerebral aneurysms: The long-term data for unruptured aneurysms are still being gathered. Click anehrysm image for details. In patients with ruptured intracranial aneurysms suitable for both treatments, endovascular coiling is more likely to result in independent survival at 1 year than neurosurgical clipping; the survival benefit continues for at least 7 years.