PDF | Libidibia ferrea, popularly known as “pau ferro” or “jucá”, is an important medicinal plant employed for the treatment of various ailments in. Genus: Libidibia (formerly known as Ceasalpinia). species: ferrea. Family: Fabaceae. Common Name: Leopard tree, Brazilian Ironwood. Description. Unarmed tree, to 15 m. Bark very distinctive, smooth, grey, pealing to reveal paler patches. Leaves 2-pinnate; pinnae in pairs, each with

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Only F80 showed some cytotoxic activity; CE did not present cytotoxicity against the cell lines used. To receive news and publication updates for BioMed Research International, enter your email address in the box below.

Support Center Support Center. Besides, the bark is used for enterocolitis, diabetes, and rheumatism treatment [ 6 ]. Acetic acid causes algesia by releasing endogenous substances, which then excite the pain nerve endings; the abdominal constriction is related to sensitization of nociceptive receptors to prostaglandins [ 41 ]. Retrieved from ” https: Assays revealed that the extract reduced the edema formation significantly from the first moments.

Donor mice were anaesthetized for tumor suctioning, and the ascitic form of the tumor was introduced under the right axilla of the receptor animals. Evid Based Complement Alternat Med. Using the acetic acid-induced writhing response, which is the visceral pain model, the analgesic mechanism of abdominal writhing involves different nociceptive mechanisms, such as the process or release of arachidonic acid metabolites via cyclooxygenase and prostaglandin biosynthesis, opioid mechanisms, local peritoneal receptors and mediators related to acetylcholine and histamine, and sympathetic system mediators [ 353940 ].


These results indicate that CE and F80 showed analgesic action in addition to anti-inflammatory activity. Therefore, both extract and fraction presented low cytotoxicity. Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages. Maria Barbosa Reis da Silva and Mr. Modulating leukocyte recruitment in inflammation.

Anti-inflammatory compounds of plant origin—part II.

Simon Schubert is a qualified Horticulturist who enjoys gardening and bush-walking. Inhibition percentage was calculated through the decrease of total number of writhings in the treated groups against the control group. Naloxone and atropine were able to reverse LPLF antinociception. Cancer chemopreventive effects of a Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis. libidbiia

Methyl esters profile of the fatty acids in LPLF. Articles from Evidence-based Complementary and Alternative Medicine: Pitting between vessels is alternate and covered, and fibres are generally not divided by a septum. Histochemical tests were carried out using free-hand sections of newly collected material and included the Sudan IV test for lipids, Osmium tetroxide test for unsaturated lipids, and Nile blue sulphate test to neutral and acids lipids.

The hot-plate test was used to measure the response latencies according to the method described previously [ 12 ]. View at Google Scholar C.

The saturated fatty acids were found in a minor concentration in LF extract. Then, the antitumor effect of Caesalpinia spp. Hot-Plate Test The hot-plate test was used to measure the response latencies according to the method described previously [ 12 ].


Preliminary studies of analgesic and anti-inflammatory properties of Caesalpinia ferrea crude extract. In the meantime, C.

Mutational analysis of the analgesic peptide DrTx 1—42 revealing a functional role of the amino-terminal turn. This article has been cited by other articles in PMC.

Libidibia ferrea

Cell Viability — Trypan Blue 0. Lins2 L. After collecting the material, seeds of Libidibia ferrea were separated for extraction. Carneiro-da-Cunha1 T.

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These results are more significant from those found by Carvalho et al. A mesotest composed of osteosclereids and several layers of fibers, and an endotest composed of an inner surface; the space between the exotest and the cotyledon was occupied for endosperm Figure 2 a.

In a previous approach, Carvalho et al. This page was last edited on 16 Augustat Several reports support a role for acetylcholine ACh in the inhibition and modulation of the transmission of nociceptive information [ 3839 ]. On the other hand, the same stimuli could be activating MyD88, which activates the Akt pathway.

Saline control ; the standard drugs: Since CE and F80 were confirmed to have anti-inflammatory activity in carrageenan-induced peritonitis Figure 2 and Table 1their analgesic activity was examined.